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To enhance model robustness and generalisability, harmonisation techniques (NeuroComBat and Maximum Independence Domain Adaptation) were applied to reduce inter-site differences

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NHS and BNF recommendations typically include: Oral cyanocobalamin 50150 micrograms daily for dietary deficiency Intramuscular hydroxocobalamin for malabsorption or neurological involvement (initially 1 mg every other day for 1-2 weeks for neurological symptoms, or 1 mg 3 times weekly for 2 weeks without neurological symptoms