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As the duration of the pre-dose fasting period decreased, there was a corresponding decrease in semaglutide exposure

The .25mg dose is designed as a starting and titration phase, not a maintenance dose for most patients

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Mol Metab 20:5162 Muller TD, Finan B, Bloom SR, DAlessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschop MH (2019) Glucagon-like peptide 1 (GLP-1)

Frontiers in Endocrinology, 14, 1209975