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Direct beneficial effects of GLP-1 agonism on retinal vasculature have also previously been reported in animal models [27], which could potentially offer another mechanism by which risks of EWDR associated with rapid HbA 1c reduction might be mitigated

Semaglutide is ideal for individuals with a body mass index (BMI) of 30 or greater or for adults with a BMI of 27 who also have at least one weight-related complication such as hypertension, insulin resistance, high cholesterol, or heart disease

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Its not fully clear how semaglutide helps with knee pain from osteoarthritis

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