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Patients who may particularly benefit from GLP-1 receptor agonists include those with type 2 diabetes and established cardiovascular disease, obesity, or chronic kidney disease (where SGLT2 inhibitors are not suitable or as additional therapy)
Structure-Activity Relationships and Medicinal Chemistry The optimization of orforglipron from the initial hit compound to a clinical candidate exemplifies modern medicinal chemistry approaches applied to a novel target class

Only patients in the former group experienced significant lowering of body weight and had maintained BMD levels, after 44 weeks of treatment (14)

Visco DB, Manhes-de-Castro R, Chaves WF
