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The lowest doses produced the smallest increases
Also, due to the important role of endothelial dysfunction in CVD, the effects of GLP-1RA on flow-mediated vasodilation (FMD) in patients remain to be investigated for their contribution to the CVD actions of GLP-1RAs

BNP, B-type natriuretic peptide

The total protein content was determined with BCA protein assay (TaKaRa, Shiga, Japan)

These efforts, along with implementing diet and lifestyle changes, will provide the most effective and sustainable outcomes and help inform the decision of whether to use medications or not.