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To date, there has been no clear evidence of an associated increase in cardiovascular events in the relatively short phase 2 studies

This work was supported by the National Natural Science Foundation of China (Grant No

Thyroid C-Cell Tumors: In mice and rats, semaglutide caused an increase in thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

The primary endpoint was to demonstrate non-inferiority (with a non-inferiority margin of 0.3%) of tirzepatide 10 mg or 15 mg, or both, compared to glargine in terms of the change in HbA1c from baseline to 52 weeks