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These studies demonstrate that localized GLP-1R activation enhances cholesterol efflux, reduces plaque lipid burden, and suppresses inflammatory gene expression even at doses too low to alter systemic metabolic parameters

After entering the liver NEFAs: (i) can be transported into the mitochondria and metabolized through -oxidation

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The cohort for the main analysis excluded patients with any non-thyroid cancer in the previous year before cohort entry

These symptoms typically peak within 24 to 72 hours after the injection and gradually improve over the following week