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Variants in genes like FTO rs9939609 and MC4R rs17782313 can affect how strongly an individual's brain responds to reward signalsa factor that may influence both overeating and nicotine dependence

B2 cells that participate in the immune system are pro-inflammatory factors that can promote NASH-associated liver fibrosis ( H 2 and T H 17 cells have a pro-fibrogenic impact ( H 17 can stimulate the formation of transforming growth factor- (TGF-), which promotes fibrosis by activating fibroblasts ( + PD1 + T cells in mice and humans with NASH ( + T cells attract HSCs with high expression of CCR5 and lead them to apoptosis via the FasL-Fas pathway, which results in the resolution of liver fibrosis ( 3.2 The abnormal lipid metabolism and lipid accumulation cause steatosis and lead to inflammation and MASLD Abnormal lipid metabolism is a crucial cause of MASLD

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doi:10.1007/s13300-020-00894-y 45

Bariatric surgery promoted the GLP-1 secretion Bariatric surgery, which alters gut microbiota ecology, improved obesity and T2D well (11, 162)