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This disruption may explain why some patients present with hollowing, sagging, and an overall dullness that feels out of proportion to their weight loss alone

Additionally, severe gastrointestinal side effects can occasionally lead to dehydration and electrolyte imbalances, which may indirectly affect cardiac function

Indian Journal of Psychological Medicine , vol

The addition of GCGR to GLP-1 is additive but not as powerful as the addition of GIP to GLP-1 - a counterintuitive result given the strength of Retatrutide's glucagon-driven signal, and one that underscores how much of the triple-agonist story is about the combination of the three receptors rather than the magnitude of any single one

If youre maintaining your weight, you may stay on the same dose