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Description
One possibility is that GLP-1R endocytosis is required for agonist uptake by the brain via hypothalamic tanycytes, as described for leptin 65

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But once the shortage ends, the patent is back to being enforced, and no other copies are allowed

In contrast, CGN has been shown to inhibit the growth of syngeneic adenocarcinomas tumors in C3H mice (Thomson and Fowler 1977 Thomson, A