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If GLP-1 agonists show superior neuroprotective benefits, this could challenge the traditional treatment paradigm and support initiating therapy with GLP-1 agonists in selected patients. GLP-1 agonists have demonstrated mechanisms that include reducing neuroinflammation, enhancing cerebral glucose metabolism, and improving synaptic plasticity, Wu added

Rosenstock J, Frias J, Jastreboff AM, Du Y, Lou J, Gurbuz S, Thomas MK, Hartman ML, Haupt A, Milicevic Z, et al

Nevertheless, the untangling of the incretin system promises to deliver further gains in our efforts to translate future knowledge into therapeutic benefit for patients

This is a meaningful practical benefit that most patients do not think to use when first enrolling