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Side-effect data reported below come from per-compound Phase 2/3 trials and the closest-analog REDEFINE 1 cagrilintide+semaglutide trial

What the Research Shows Recent research on semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) has revealed concerning trends about body composition changes: A 2023 analysis of STEP trial data found that approximately 39% of weight lost on semaglutide was lean body mass 1 Research on tirzepatide showed similar patterns, with 30-40% of total weight loss coming from lean tissue 2 Comparative studies indicate GLP-1 users may lose more muscle than people losing weight through diet and exercise alone 3 For context: if you lose 50 pounds on a GLP-1 medication, 15-20 pounds might be muscle mass

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Adonis Saremis triple board certification and specialization in Obesity Medicine means your Ozempic program is managed with full evidence-based clinical expertise not a treatment algorithm designed for volume

This hormone is also what powerful new drugs like Ozempic and Mounjaro mimic, stimulating weight loss