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GLP-1 affects renal function by decreasing water intake as well as by stimulating the excretion of urine and sodium (Figure 7)
It is also a substrate for sirtuins, a family of NAD+-dependent deacetylases that regulate metabolism, inflammation, and aging
Over a 13-month period, persistence drops to just 32%, compared to 41% for diabetes GLP-1s
Central serotoninergic signaling also regulates food intake
