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10.1016/j.cell.2009.05.035 29 CourtneyM.GjernesE.DruelleN.RavaudC.VieiraA.Ben-OthmanN.et al (2013)

Mechanism of Action Metformin decreases hepatic glucose production and improves hepatic insulin sensitivity but has only a modest impact on peripheral insulin-mediated glucose uptake (i.e., insulin resistance), which is likely due to a reduction in hyperglycemia, triglycerides, and free fatty acid levels (48,49)

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