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The relative contribution of ERR/ varies by tissue context, and cross-talk with PPARs, AMPK, and HIF pathways can influence observed phenotypes

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Switch to smaller, more frequent meals if three big meals a day feels like too much, and choose whole, nutrient-dense foods over ultra-processed foods as much as possible

European Journal of Clinical Nutrition, 79(2), 90103

However, as expounded earlier, they may be commenced for their more robustly demonstrated efficacy in preventing depressive relapses in BD-II.[20] Modified ECT can be considered as a second-line treatment option in patients who respond poorly to pharmacological treatment, or as a first-line option for those at high risk of suicide or needing a rapid response