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(2025) reported that preconception or early-pregnancy GLP-1 RA exposure was associated with greater gestational weight gain and higher risks of preterm delivery, gestational diabetes and hypertensive disorders of pregnancy

A prespecified 104-week extension in the BMI 35 subgroup showed continued loss reaching 30.3% with no plateau at 80 weeks

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Weight loss continued past the 80-week primary endpoint rather than plateauing, which is the question every obesity drug has to answer eventually

Resistance training results in increased protein synthesis in the muscles and their composition and function