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This pharmacological effect, while beneficial for glycemic control and weight loss, may exacerbate gastrointestinal symptoms in individuals with active or poorly controlled celiac disease

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The diabetes-induced reduction of neurogenesis in the hippocampal dentate implies a potential mechanism for diabetes-related cognitive decline.105110 A possible explanation is that pro-inflammatory factors in type 2 diabetes compromise endothelial caveolin-1, a major membrane intrinsic protein in the caveolae on the cell surface, leading to vascular dysfunction, affecting neurogenesis, and subsequently leading to AD.111 IKK/NF-B-mediated impairment112 and -aminobutyric acid and glutamate transporter systems113 may also be involved in diabetes-induced damage of neurogenesis