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This helps ensure accurate comparisons over time

Some protocols incorporate cycling, using a 5-days-on, 2-days-off schedule to maintain pituitary sensitivity and prevent receptor downregulation
Long-term opioid therapy often leads to reduced analgesic efficacy, requiring higher doses that increase the risk of dependency and adverse effects [79]
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BAT is activated by various stimuli, including exposure to cold, and stimulates the metabolism of fat and sugars
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