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It would be helpful to see more research in this area and make a consideration for changing dosing based on gender. Mir B

All patients received a standard lifestyle intervention which included instruction on a reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity counseling (recommended minimum of 150 min/week) that began with the first dose of ZEPBOUND, during the lead-in period, and continued throughout the trial

The best medication for you will be the one you can take safely and consistently and the one that delivers the benefits youre looking for

It is administered subcutaneously once per week with a recommended starting dosage of 2.5 mg

But "not contraindicated" is different from "safe and risk-free." Here is a practical framework based on the pharmacology and clinical evidence