glp-1 lemme 37399915_web1_M1-FWM20240917-Lemme-GLP-1-Daily–Teaser Nutritionist Dr. Lisa Moskovitz Supplement

Endogenous GLP-1 has a short half-life (23 minutes) and is rapidly metabolised after its secretion via the enzyme dipeptidyl peptidase (DPP-4), while GLP-1RAs have a prolonged half-life of approximately 7 days [2, 3], resulting in some long-lasting effects

From the clinical perspective, GLP-1R gene polymorphism is associated with AUD, and exenatide moderately reduces alcohol drinking in overweight AUD patients

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This warning is based on findings in rodent studies where these drugs caused thyroid C-cell tumors (medullary thyroid carcinoma) at clinically relevant exposures

While Semaglutide GLP-1 can aid in appetite control, making these lifestyle changes is key to success