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The combination of delayed gastric emptying, direct hypothalamic appetite regulation, and peripheral metabolic effects achieves sustained weight reduction, approaching levels comparable to those of bariatric surgery with the most advanced agents [70,71]

Phentermine carries FDA approval only for short-term use, defined as up to 12 weeks

Food and Drug Administration (FDA) as weight loss medications

To further determine whether GLP-1R and PKA signalling were involved in the regulation of metformin functions in HUVECs, the protein levels of GLP-1R and phosphorylated PKA (p-PKA) were examined

Researchers are still exploring the full extent of these brain effects, but the impact on appetite control is a key part of how these medications aid in weight management