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Fras JP, Davies MJ, Rosenstock J et al (2021) Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes

Yes rapid weight loss can reduce facial volume, leading to under-eye hollowing, deeper tear troughs, or a more tired, "sunken" look sometimes called "Ozempic face." Upper eyelids may also appear heavier

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That makes it a very well-documented GLP-1 tool for research models