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[DOI] [PubMed] [Google Scholar] 42.Lundgren J.R., Janus C., Jensen S.B., et al

It tells the pancreas to produce insulin, slows gastric emptying, and signals to the brain that food has arrived

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This strategy was based on previous structural data showing that position 5 of the FFAT core motif is located within a hydrophobic pocket in the MSP domain of VAP 41 , with previous studies indicating that introducing a negative charge in this position causes a steric hindrance which effectively disrupts FFAT motifVAP interaction 42