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[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Deganutti G., Liang Y.L., Zhang X., Khoshouei M., Clydesdale L., Belousoff M.J., Venugopal H., Truong T.T., Glukhova A., Keller A.N., et al

Additionally, eating your largest meal earlier in the day and consuming smaller portions at dinner allows your digestive system more time to process food before sleep, which can improve regularity
From a pharmacological perspective, tirzepatide acts primarily through GIP and GLP-1 receptor pathways to modulate insulin secretion, glucagon suppression, and appetite regulation

If you have fatigue, cold sensitivity, constipation, dry skin or unexplained weight gain, your provider may recommend thyroid testing

Some early research suggests GLP-related signalling may influence pain sensitivity, bowel habits and gut motility in IBS, but were nowhere near a one size fits all answer