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Results at 72 weeks: Placebo: 3.1% weight loss Tirzepatide 5 mg: 16.0% weight loss (35.3 pounds average) Tirzepatide 10 mg: 21.4% weight loss (49.7 pounds average) Tirzepatide 15 mg: 22.5% weight loss (52.3 pounds average) The percentage of participants achieving 5% or more weight loss was 89% (5 mg), 96% (10 mg), and 96% (15 mg)

persistent or severe diarrhea warrants medical consultation Vomiting may occur particularly in the first few weeks of treatment Constipation affects some patients, potentially requiring dietary modifications or over-the-counter remedies Abdominal pain or discomfort usually mild and transient Decreased appetite an expected pharmacological effect that contributes to weight reduction These gastrointestinal effects are generally dose-dependent and tend to diminish over time as the body adapts to the medication

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It also contains small amounts of iron, calcium and potassium

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