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Neutral buffered formalin was used for 24 h to fix the cardiac tissue, after fixation dehydration was performed with a series of upscale alcohol solutions and the tissue was embedded in paraffin

Clinical confirmation is pending, but the physiological rationale is strong

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Clinical trials and post-market surveillance show that GLP-1 receptor agonists like semaglutide can be used continuously for weight management when medically appropriate, with duration determined by individual response, tolerability, and clinical goals rather than a preset time limit

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