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ii) Cardiovascular death: Excluding the SOUL trial strengthened the effect (shifting from non-significant to significant), suggesting sensitivity to SOUL but moderate robustness due to consistent overall effect direction and magnitude
The retatrutide dosage chart reflects how these effects scale with increasing doses through the titration protocol
For a middle-aged patient with creeping weight gain and a family history of heart disease, starting oral semaglutide can be the decisive factor that prevents a future heart attack
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