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Methods Insl5 promoter-driven expression of Gq-coupled Designer Receptor Exclusively Activated by Designer Drugs (DREADD) was employed to activate distal colonic L cells (L distalDq )
Kidney effects Both medications can be used in patients with any level of kidney function, as neither drug relies on renal clearance
ANCOVA with the fixed factor treatment and the basal value as covariate was used to compare the change score between the groups
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