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The potential of GLP-1RAs to reduce alcohol consumption in humans was first reported at a scientific conference in 2011.141 An RCT157 evaluated the effect of 26 weeks of once-weekly exenatide treatment on the frequency of heavy drinking days in patients diagnosed with AUD

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The standard reference agonist is GLP-1, which is tested in each experiment at several concentrations to generate a concentration-response curve from which its EC 50 value and SE is calculated using GraphPad Prism

Avicenna J

During the median follow up of 15.9 months, 3.8% of the patients assigned to the study group experienced the primary outcome compared to 4.8% among those in the placebo