estimated revenue glp-1 drugs Antagonists Increase Plan Drug Spend - What's Next GLP-1s lead drug sales

They draw water into the bowel, softening stools and increasing frequency Bulk-forming laxatives (ispaghula husk, methylcellulose) work similarly to dietary fibre and are generally suitable for long-term use, but should be avoided if you have severe bloating or suspected impaction Stimulant laxatives (senna, bisacodyl) should be reserved for short-term use when other measures fail Rectal treatments (glycerol suppositories, small-volume enemas) can provide rapid relief for occasional constipation Establishing a regular toilet routine can be beneficial

Meanwhile, Wegovy is facing tough competition from Eli Lilly's weight-loss therapy Zepbound (tirzepatide), which outperformed its rival in the head-to-head SURMOUNT-5 trial

The most important thing to know: prepare before you start, not after the problem begins

[DOI] [PubMed] [Google Scholar] 674.Scott K.A., Moran T.H

Transplantation Proceedings, 44 (8), 24956