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Importantly, initiation of GLP-1RA may decrease levothyroxine dose requirements in patients with hypothyroidism through weight loss, enhance levothyroxine absorption due to delayed gastrointestinal (GI) transit, and have direct effects on the hypothalamic-pituitary-thyroid axis [2329], potentially increasing the risk of thyroid hormone over-replacement (i.e., iatrogenic hyperthyroidism)

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The test identifies genetic variants affecting GLP1R and GIPR sensitivity, which influence dose tolerance and side-effect risk

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