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The underlying reason is the same as in primary carnitine deficiency

Interestingly, compared with the model group, the TC and TG contents of the Lira group had a decreasing trend but the difference was not statistically significant

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A large-scale genome-wide association study published in Nature in April 2026, conducted by 23andMe researchers using data from 27,885 GLP-1 medication users, identified a specific variant in the GLP1R gene the gene that encodes the primary receptor these drugs target associated with differential weight loss efficacy