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The mechanism has been suggested to involve inhibition of cardiac intracellular signaling pathways (Ca 2+ /calmodulin-dependent protein kinase II and protein kinase C) due to saxagliptin-mediated inhibition DPP-9 (136)
The irony is brutal
Baggio et al., Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans, Nat
These approaches address the root cause rather than masking symptoms
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