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Here, we review the pharmacokinetics, pharmacokinetic drugdrug interactions (DDIs), and pharmacokinetic modeling approaches of four currently available GLP-1 RAs (exenatide, liraglutide, dulaglutide, and semaglutide) and tirzepatide

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Tirzepatide and renal outcomes Tirzepatide Tirzepatide is a dual GIP/GLP-1 receptor agonist designed to engage complementary mechanisms and elicit synergistic and more efficacious responses with respect to monoagonists [39]

Additionally, these studies had much heterogeneity owing to the inclusion of different outcomes and different comparator drugs