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GLP-1 receptor agonist liraglutide exerts central action to induce -cell proliferation through medulla to vagal pathway in mice

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Subtle conformational dynamics allow the C-terminus of GLP-1 to access the ECD binding site, and the ligand binding triggers further dissociation of the ECD from the TMD allowing the N-terminus of GLP-1 to enter the orthosteric pocket in the TMD and activate the receptor

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