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Even though POTS patients were not obese, the absence of hypoglycemia in response to an enhanced C-peptide and insulin secretion suggests reduced insulin sensitivity, which was later confirmed by a significantly lower Matsuda index in POTS patients

These types of data and the difficulty to manufacture a peptide like GLP-1, raise the barriers to entry for the duopolist market leaders

MW: Writing original draft, Supervision, Data curation

With thoughtful management, most patients stabilize and recover normal growth

Here, we found infusions of GIP(3-30)NH 2 to cause higher plasma glucose levels, indicating a glucose-lowering effect of endogenous GIP