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Description
The presence of GLP-1R on vagal afferent nerves plays a key role in this effect

One issue to be solved may be the differential expression patterns of SGLT-2 in CNS between human and rodents, although some studies have attempted to describe central distribution and the related function

Thus, the decreased cardiorenal risk associated with the combined use of GLP1-RAs/SGLTis may be attributed to an additive effect, achieved by the distinct mechanisms and sites of action for these different drug classes [13]

Ignoring visual changes

Abbreviations BAT: Brown adipose tissue CEX: C-terminal extension CNS: Central nervous system DIO: Diet-induced obese DPP-IV: Dipeptidylpeptidase-IV EMA: European Medicines Agency FDA: Food and Drug Administration GcgR: Glucagon receptor GIP: Glucose-dependent insulinotropic polypeptide GIPR: GIP receptor GLP-1: Glucagon-like peptide 1 GLP-1R: GLP-1 receptor OXM: Oxyntomodulin PEG: Polyethylene glycol STZ: Streptozotocin T 3 : Thyroid hormone References Obesity and overweight fact sheet
