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Zepbound costs between $25 and $1,086 per month in 2026

Side Effects Semaglutide: Common Side Effects: Nausea Vomiting Diarrhoea Constipation Abdominal pain Less Common Side Effects: Headache Fatigue Dizziness Hypoglycaemia (especially in individuals with type 2 diabetes) Pancreatitis (rare but serious) Tirzepatide: Common Side Effects: Nausea Vomiting Diarrhea Constipation Abdominal pain Less Common Side Effects: Decreased appetite Dyspepsia (indigestion) Injection site reactions Hypoglycemia (more common when combined with insulin or sulfonylureas) Pancreatitis (rare but serious) Administration Semaglutide: Administered via injection

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Overview of NICE TA1026 Tirzepatide is recommended by NICE (2024) for managing obesity alongside a reduced-calorie diet and increased physical activity in adults, only if they have: An initial BMI of at least 35 kg/m 2 , and At least one weight-related comorbidity

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