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-HB suppresses NLRP3 inflammasome activation and reduces inflammation independently of its role as a metabolic substrate or canonical signaling pathways, suggesting that -HB contributes to the anti-inflammatory effects of energy restriction [7]

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2022Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes

The reduction in visceral fat is particularly significant, as this type of fat directly drives inflammatory cytokines that activate HPA axis signaling