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By contrast, peptides such as PYY and apelin were discontinued primarily due to formulation limitations or tolerability at supraphysiologic dosespharmacologic rather than biological failuresand therefore meet criteria for re-evaluation

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doi: 10.1111/dom.14553 [DOI] [PMC free article] [PubMed] [Google Scholar] 45.Farah C, Michel LYM, Balligand JL

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The question is whether microdosing influences it strongly enough to produce measurable metabolic results