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Description
Building on these results, a phase 1b trial in individuals with T2D further evaluated the safety, pharmacokinetics, and pharmacodynamics of once-weekly retatrutide over 12 weeks [43]

Semaglutide for Obesity (NEJM, 2025) Rodriguez et al

Dose equivalence comparison These equivalences are approximate and based on clinical outcome comparisons rather than direct pharmacological matching

Tirzepatides maximum weekly dose is 15 mg for both type 2 diabetes and obesity

Washington TB, Johnson VR, Kendrick K, et al
