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In some cases, patients reduced or discontinued antianxiety medications after starting semaglutide, though this should only occur under physician supervision

The semaglutide group experienced fewer serious adverse events compared to placebo ( 49.6% versus 53.8%), but more adverse events leading to discontinuation ( 13.2% versus 11.9%)

Lower use among those ages 65 and older (9%) likely reflects Medicares lack of coverage for drugs prescribed specifically for weight loss

Regulatory changes : The FDA has been tightening rules around compounding, especially for GLP-1 medications, so availability can shift quickly

When combined with lifestyle changes and correct management, these medications can be extremely powerful