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The 2018 market introduction of both potent and easy to use once-weekly Ozempic will likely again alter the GLP-1 RA prescribing landscape

Although the exact mechanism of action remains an area of interest, there are hypotheses as to why incretin analogs and GLP-1RA are effective in FPLD

This paper contains this figure, about which everyone is going crazy: I admit this looks good

2 Although several currently used T2D medications, such as metformin and TZDs, indirectly activate AMPK, no direct AMPK activators have made it to the clinic due to poor pharmacokinetic profiles or off-target effects

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