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In patients with type 2 diabetes and high cardiovascularrisk, clinical trials have shown that GLP-1 receptor agonistsreduce the incidence of major adverse cardiovascular events.The effect of tirzepatide a dual incretin agonist of theGLP-1 and GIP receptors on cardiovascular outcomes isuncertain. In theSURPASS-CVOTtrial, patients40 years of age or older with type 2 diabetes, a BMIof at least 25, and atherosclerotic cardiovascular disease wererandomly assigned to receive a weekly subcutaneous injectionof tirzepatide (up to 15 mg) or dulaglutide (1.5 mg), a GLP-1receptor agonist that has been shown to reduce the incidenceof cardiovascular events

Its dual-incretin mechanism may offer enhanced metabolic benefits compared with selective GLP-1 receptor agonists such as semaglutide

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