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For example, different actions of GLP-1 receptor agonists such as delaying gastric emptying which leads to a prolonged feeling of fullness and reducing food intake lead to significant weight loss ( Endogenous GLP-1 has a short half-life since it is in 1-2 minutes degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)

As treatment continues and side effects improve, keeping track of nutrition becomes very important

the first is when a rapid pharmacological effect is required, such as with anti-hyperglycemic drugs that affect immediate post-prandial glucose excursions [48, 54]