tirzepatide palpitations Can Cause Heart Palpitations? Exacerbation of Postural Orthostatic Tachycardia

2022;119:e2117640119 Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ

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Neuroprotection: GLP-1s cross the blood-brain barrier and act on microglia, supporting brain and mood health

Emergency physicians have a 90% success rate at treating epistaxis in emergency department, and only have to refer 10% to ENT for further assessment and management Causes of Epistaxis: Local trauma: Nose picking Facial trauma Foreign bodies Nasal or sinus infections Nasal septum deviation Environmental: Dry cold conditions (presentations increase during winter) Prolonged inhalation of dry air (Oxygen) Iatrogenic: Nasogastric tube insertion Nasotracheal intubation Medicinal: Topical corticosteroids and antihistamines Solvent inhalation (huffing) Snorting cocaine Anticoagulants: Aspirin, warfarin, platelet inhibitors Coagulopathies: Inherited coagulopathies: von Willebrand disease, haemophilia A & B Splenomegaly Thrombocytopenia Platelet disorders Liver disease Renal failure Chronic alcohol abuse AIDS Vascular Abnormalities: Sclerotic vessels Hereditary haemorrhagic telangiectasia Arteriovenous malformation Neoplasm Aneurysms Septal perforation/deviation Endometriosis Hypertension: Controversial topic and is often misunderstood in epistaxis see Hypertension and Epistaxis

Eli Lilly's branded tirzepatide product is licensed in the UK as Mounjaro (type 2 diabetes) and in the US additionally as Zepbound (chronic weight management)