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What to Expect Most patients begin noticing results within the first few weeks, with continued improvement over time

The GLP-1R is rapidly internalized when activated by its cognate agonist 9 , but the effect of internalization and subsequent post-endocytic trafficking on overall GLP-1 responses is not clear

Lindstrm J, Peltonen M, Tuomilehto JFor the Finnish Diabetes Prevention Study Group Lifestyle strategies for weight control: experience from the Finnish Diabetes Prevention Study

Maybe you can comment a little bit on that aspect and what we think the GLP-1s are doing in a positive, but also maybe in a pathological way there

Diabetes Obes Metab, 14:596-600