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Before initiating tirzepatide, clinicians should obtain a thorough personal and family history focusing on thyroid disease, particularly any history of medullary thyroid carcinoma or MEN 2 syndrome

While ESSENCE monitored hepatic function tests every 12 weeks, semaglutide has demonstrated a favorable hepatic safety profile in this and prior studies

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These structural interfaces are defined as regions in which organelle membranes are brought into proximity, typically within 1080 nm, thereby enabling direct communication and non-vesicular exchange of ions, lipids, and signaling molecules without membrane fusion (Cali et al., 2025)