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Diabetes Obes Metab 2020;22:248792

With once-daily liraglutide, another GLP-1 receptor agonist approved for the treatment of type 2 diabetes at doses of up to 1.8 mg, body weight and sex were found to be the most important covariates for exposure which, however, did not influence liraglutide PK to any clinically relevant degree [13]

New JAMA Study Links Wegovy to NAION A JAMA study published on July 3, 2024, on the Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide found an increased risk of the condition in patients taking semaglutide compared to those taking non-GLP-1 RA medications

Effective compound exercises include: Squats: Target quadriceps, hamstrings, and glutes

Based on Phase 2 trial data (Jastreboff et al., NEJM , 2023), the most commonly reported adverse effects of retatrutide include: Gastrointestinal effects: Nausea, vomiting, diarrhoea, and constipation (most frequent, particularly during dose escalation) Injection site reactions: Redness, bruising, or mild discomfort Decreased appetite: Generally considered a therapeutic effect but can contribute to nutritional deficiency if severe Increased heart rate: Observed with glucagon receptor agonism