glp-1 news Alarming rise in weight loss drug overdoses As GLP-1 Drugs Go Mainstream,

In July 2024, Amylyx Pharmaceuticals, a clinical-stage biopharmaceutical company, acquired Avexitide from Eiger Biopharmaceuticals

COMT normally converts: Levodopa 3-O-methyldopa (3-OMD) Dopamine metabolism also increases Tolcapone blocks COMT Increases levodopa levels in blood Increases levodopa delivery to brain Prolongs levodopa duration of action Reduces wearing-off symptoms Reduces motor fluctuations Special Point: Tolcapone inhibits COMT both in peripheral tissues and in the CNS, unlike entacapone (mostly peripheral)

Drug Type/Class 17.6.3

However, the added agonism of GIPR seems to have a more positive impact on weight loss

Studies have shown that GLP-1RA regulate MAPK signaling pathway through GLP-1R to play the anti-diabetes, anti-tumor and anti-atherosclerosis effects (Nomiyama et al., 2014